Qianqian Fang, Ph.D.

Contact

Title	Instructor
Institution	A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital (Harvard Medical School)
Address	Bldg 149, 13th Street, Charlestown, MA 02148
Email	fangq < at > nmr.mgh.harvard.edu
Telephone/Fax	(617)726-9332 [Office], (617)407-5769 [Cell], (617)726-7422 [Fax]

Education

Ph.D. in Biomedical Engineering

Date: 12/2004
Institution: Thayer School of Engineering at Dartmouth College, Hanover, NH 03755, USA
Dissertation: “Computational methods for microwave medical imaging”
Thesis Committee: Paul M. Meaney, Keith D. Paulsen, William Lotko, Eric L. Miller

Bachelor of Engineering in Electrical Engineering 7/1999

Institution: Univ. of Electronic Sci. & Tech. of China (UESTC), Chengdu, Sichuan 610054, China
Major: Electromagnetic Field and Microwave Technology
Diploma Project: “Time domain analysis and applications of transient electromagnetic field”
Advisor: Zaiping Nie

Research and Professional Experience

Instructor	MGH/MIT/HMS A. Martinos Center for Biomedical Imaging	2009~Present
Research Fellow		2/2005~2009
My research focuses on the clinical study of breast cancer using diffuse optical tomo-graphy (DOT) and tomosynthesis, investigation of optical contrast and dynamic signa-ture of breast tissue under compression, algorithm design for optical breast and multi-modal brain functional imaging, in vivo experiments and data analysis for breast/brain functional imaging, development of general-purpose image reconstruction software.

Research Assistant Thayer School of Engineering, Dartmouth College 9/2000~1/2005

I was a key member for developing a new generation microwave medical imaging sys-tem for breast cancer detection and thermal therapy. Specifically, I focused on algo-rithm design and software development, including 3D fast forward/inverse scattering algorithms, multi-spectral image reconstruction, phase unwrapping theory, regulariza-tion, adjoint method and singular value spectrum analysis. My effort also includes in vivo animal and clinical experiments and extensive data processing.

Research Assistant	Thayer School of Engineering, Dartmouth College	9/2000~1/2005
I was a key member for developing a new generation microwave medical imaging sys-tem for breast cancer detection and thermal therapy. Specifically, I focused on algo-rithm design and software development, including 3D fast forward/inverse scattering algorithms, multi-spectral image reconstruction, phase unwrapping theory, regulariza-tion, adjoint method and singular value spectrum analysis. My effort also includes in vivo animal and clinical experiments and extensive data processing.

Research Assistant Antenna (Computational Electromagnetics) Lab, UESTC 3/1999~8/2000

I implemented finite difference-time domain (FDTD) method with PML absorbing boundary condition in electromagnetic pulse well-logging, and wrote data-acquisition software for real-time EM scattering measurement.

Research Assistant	Antenna (Computational Electromagnetics) Lab, UESTC	3/1999~8/2000
I implemented finite difference-time domain (FDTD) method with PML absorbing boundary condition in electromagnetic pulse well-logging, and wrote data-acquisition software for real-time EM scattering measurement.

Research Assistant Microwave Lab, UESTC 9/1996~3/1999

I actively participated the development of high performance millimeter microwave switches, and was involved in circuit modeling, optimization, schematics, and testing.

Research Assistant	Microwave Lab, UESTC	9/1996~3/1999
I actively participated the development of high performance millimeter microwave switches, and was involved in circuit modeling, optimization, schematics, and testing.

Professional Membership

Publications

Book Chapter

Fang Q, Carp S, Selb J, Boas D, “Chapter 9. Optical Imaging and X-ray Imaging”, [Translational multimodality Optical Imaging], Fred S. Azar, Xavier Intes (Eds.), Artech House, Norwood, 2008
Meaney PM, Fang Q, “Chapter 7. Microwave imaging: A model-based approach”, [Alternative Breast Imaging-Four Model-Based Approaches], Paulsen KD, Meaney PM, Gilman L(Eds.), Kluwer, 2004.

Journals Articles

Fang Q and Boas D, "[Monte Carlo Simulation of Photon Migration in 3D Turbid Media Accelerated by Graphics Processing Units]," Optics Express, vol. 17, issue 22, pp. 20178-20190 (2009)
Fang Q, Selb J, Carp SA, Boverman G, Miller EL, Brooks DH, Moore RH, Kopans DB, Boas DA, “Combined Optical and X-ray Tomosynthesis Breast Imaging,” Radiology, (submitted).
Fang Q, Meaney PM, Paulsen KD, “Viable three-dimensional microwave imaging, theory and experiments,” IEEE Transactions on Antennas and Propagation, (in press).
Zhu G, Popovic M, Fang Q, “Microwave-Induced Thermoacoustics: Assisting Microwave Tomography,” IEEE Transactions on Magnetics, vol. 45, issue 3, pp. 1654-1657, Mar., 2009.
Fang Q, Carp SA, Selb J, Boverman G, Zhang Q, Kopans DB, Moore RH, Brooks DH, Miller EL, Boas DA, “[Combined optical Imaging and mammography of the healthy breast: optical contrast derives from breast structure and compression],” IEEE Trans. Medical Imaging, vol. 28, issue 1, pp. 30 – 42, Jan. 2009.
Fang Q, Sakadžić S, Ruvinskaya L, Devor A, Dale AM, Boas DA,"[Oxygen advection and diffusion in a three dimensional vascular anatomical network]," [front-cover article] of Optics Express, vol. 16, Issue 22, pp. 17530-17541, 2008.
Carp SA, Selb J, Fang Q. Moore R, Kopans DB, Rafferty E, Boas DA, “Dynamic functional and mechanical response of breast tissue to compression,” Optical Express, Vol. 16, Issue 20, pp. 16064-16078, 2008.
Boverman G, Miller EL,Brooks DH, Fang Q, Boas DA, "[Estimation and Statistical Bounds for Three-Dimensional Polar Shapes in Diffuse Optical Tomography]," IEEE Transactions on Medical Imaging, vol. 27, issue 6, pp.752 – 765, Jun 2008.
Boverman G, Fang Q, Carp SA, Miller EL, Brooks DH, Selb J, Moore RH, Kopans DB, Boas DA, "[Spatio-Temporal Imaging of the Hemoglobin in the Compressed Breast With Diffuse Optical Tomography]," Phys. Med. Biol. 52 3619-3641, 2007.
Meaney PM, Fanning MW, Raynolds T, Fox CJ, Fang Q, Kogel CA, Poplack SP, Paulsen KD, "[Initial Clinical Experience with Microwave Breast Imaging in Women with Normal Mammography]," Acad Radiol., vol. 14, pp. 207-218, 2007.
Meaney PM, Fang Q, Rubaek T, Paulsen KD, “[Log transformation benefits parameter estimation in microwave tomographic imaging],” Medical Physics, 34 (6):2014-23, Jun 2007
Carp SA, Kauffman T, Fang Q, Rafferty E, Moore R, Kopans D, Boas D, “[Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements],” Journal of Biomedical Optics, vol. 11, issue 6, Nov./Dec. 2006.
Fang Q, Meaney PM, Paulsen KD, [“The multi-dimensional phase unwrapping integral and applications to microwave tomographical image reconstruction,”] IEEE Transaction on Image Processing, vol 15, No. 11, pp. 3311-3324, Nov. 2006.
Fang Q, Meaney PM, Paulsen KD, [“Singular value analysis of the Jacobian matrix in microwave image reconstruction,”] IEEE Transactions on Antenna and Propagation, vol. 54, No. 8, pp.2371-2380, Aug. 2006.
Fang Q, Meaney PM, Paulsen KD, [“Microwave image reconstruction of tissue property dispersion characteristics utilizing multiple frequency information”], IEEE Transactions on Microwave Theory and Techniques, vol. 52, No. 8, pp. 1866-1875, Aug. 2004.
Fang Q, Meaney PM, Geimer SD, Streltsov AV, Paulsen KD, [“Microwave image reconstruction from 3D fields coupled to 2D parameter estimation,”] IEEE Transactions on Medical Imaging, vol. 23, pp. 475-484, Apr. 2004.
Meaney PM, Fanning MW, Paulsen KD, Li D, Pendergrass SA, Fang Q, Moodie KL, “Microwave thermal imaging: Initial in vivo experience with a single heating zone”, International Journal of Hyperthermia, vol. 19, pp. 617-641, 2003.
Meaney PM, Paulsen KD, Fanning MW, Li D, Fang Q, “Image accuracy improvements in microwave tomographic thermometry: phantom experience”, International Journal of Hyperthermia, vol. 19, pp. 534-550, 2003.

Peer-Reviewed Conference Papers

Fang Q, Boas D, ["Tetrahedral mesh generation from volumetric binary and gray-scale images"], [IEEE International Symposium on Biomedical Imaging (ISBI’09)], accepted.
Zhu G, Popovic M, Fang Q, “Microwave-Induced Thermoacoustics: Assisting Microwave Tomography,” 13th Biennial IEEE Conference on Electromagnetic Field Computation, OB2-1, Athens, May 2008
Fang Q, Meaney PM, Paulsen KD, [“Phase unwrapping in the presence of scattering nulls and applications to microwave imaging,”] Proceeding (425) Antennas, Radar, and Wave Propagation, Jul. 2004

Selected Conference Papers

Fang Q, Selb J, Carp S, Boverman G, Kopans D, Moore R, Boas D, “Clinical Data Analysis for the Combined Optical and Tomosynthesis Breast Imaging,” Proceedings of SPIE, vol. 6431, Feb., 2007
Fang Q, Boas D, Boverman G, Zhang Q, Kauffman T, [“Nonlinear image reconstruction algorithm for diffuse optical tomography using iterative block solver and automatic mesh generation from tomosynthesis images,”] Proceedings of SPIE, vol. 6081, Feb., 2006
Meaney PM, Fang Q, Fanning MW, Pendergrass SA, Raynolds T, Fox CJ, Paulsen KD, “Microwave breast imaging with an under-determined reconstruction parameter mesh,” 2004 IEEE International Symposium on Biomedical Imaging from Nano to Macro, Arlington, VA, 2004
Meaney PM, Fanning MW, Fang Q, Paulsen KD, “Initial experience with a microwave imaging system for monitoring temperature change in an animal model”, Engineering in Medicine and Biology Society 2001. Proceedings of the 23rd Annual International Conference of the IEEE, vol. 3 25-28 pp. 2844-2847, Oct. 2001

Patent

[Fang Q, Meaney PM, Paulsen KD, “ Microwave imaging system and processes, and associated software products,” US patent 20060241410]

Selected Presentations

"Imaging healthy and tumor breasts with spectrally constrained optical imaging with co-registered tomosynthesis," Biomedical Optics Topical Meeting (BIOMED) 2008, OSA, St. Petersburg, Mar. 2008
"Optical tomosynthesis, the future of mammography ?," Annual meeting 2007 of Radiological Society of North America (RSNA), Chicago, Nov. 2007
"Geometry modeling and nonlinear reconstruction for X-ray guided breast DOT," SPIE Photonic West, San Jose, Jan. 2006
["Second Generation Microwave Imaging System: Phantom and Early Clinical Experience"], Progress in Electromagnetics Research Symposium, Hawaii, Oct. 14, 2003
["3D Scalar Microwave Image Reconstruction Algorithm"], Poster, IEEE International Microwave Symposium (MTT-S), Seattle, Jun. 6, 2002

Journal Referee

Associate Editor

Medical Physics

Reviewer

IEEE Transactions on Medical Imaging (TMI)
IEEE Transactions on Biomedical Engineering (TBME)
IEEE Transactions on Microwave Theory and Techniques (TMTT)
IET Microwaves, Antennas & Propagation (formerly IEE Proceedings - Microwaves, Antennas and Propagation) (IET-MAP)
IEEE Transactions on Antenna and Propagation (TAP)
IEEE Antennas and Wireless Propagation Letters
IEEE Transactions on Evolutionary Computation (TEC)
Journal of Optics A: Pure and Applied Optics (JOPA)
Journal of Biomedical Optics (JBO)
Optical Letters
Optical Express (OE)
Journal of Applied Physics (JAP)
Physics in Medicine and Biology (PMB)
Philosophical Transactions A
[IEEE International Symposium on Biomedical Imaging 2009]

Research Grant Referee

National Institutes of Health (NIH) Center for Scientific Review (CSR)

Conference Session Chair

SPIE Photonics West 2009, [Multimodal Biomedical Imaging IV]

On the Media

Research Related

Mar 09, 2007: [Special report: optical breast imaging], interviewed by MedicalPhysicsWeb.

Open Source Related

Oct 31, 2007: [Free Chinese Fonts: An Interview with Qianqian Fang, Founder of the Wen Quan Yi Project], interviewed by Solidot/CNET.
Oct 24, 2006: [Wen Quan Yi: A Pioneer's Expedition] (in Chinese), interviewed by Software World.
Oct 09, 2006: [A Ride with Wiki] (in Chinese), interviewed by China Internet Weekly.
May 01, 2006: [Let Chinese Characters be Free Forever] (in Chinese), interviewed by [Dian Nao Bao].

Honors and Awards

Graduate School
IEEE EMBS Travel Award	Jun. 2004
Herbert Darling Fellowship	Sept. 2000

Undergraduate School

Honored Graduate of China Ministry of Electronics Industry Jun. 1999

Excellent Thesis Award of UESTC Jun. 1999

Outstanding Award of UESTC Nov. 1998

Shanghai Bell Scholarship Dec. 1998

Motorola Scholarship (twice) Dec. 1996, Nov. 1997

First Class Award of UESTC (twice) Dec. 1996, Nov. 1997

National First Class Award of China Undergraduate Mathematical Contest in Modeling 1997(CUMCM'97) Dec. 1997

Successful Participant Award of China Undergraduate Mathematical Contest in Modeling 1996 (CUMCM'96) Dec. 1996

Undergraduate School
Honored Graduate of China Ministry of Electronics Industry	Jun. 1999
Excellent Thesis Award of UESTC	Jun. 1999
Outstanding Award of UESTC	Nov. 1998
Shanghai Bell Scholarship	Dec. 1998
Motorola Scholarship (twice)	Dec. 1996, Nov. 1997
First Class Award of UESTC (twice)	Dec. 1996, Nov. 1997
National First Class Award of China Undergraduate Mathematical Contest in Modeling 1997(CUMCM'97)	Dec. 1997
Successful Participant Award of China Undergraduate Mathematical Contest in Modeling 1996 (CUMCM'96)	Dec. 1996

Computer Skills

Programming Languages
C/C++ (13 yr),FORTRAN (9 yr), Matlab (10 yr), Perl (6 yr), JavaScript (5 yr), HTML/CSS(10 yr), metapost (5 yr), CUDA (3 yr), UNIX Shell Scripting, SQL
OS
GNU/Linux, Tru64 UNIX, Windows
Applications
GNU development tool-chain (gcc,g++,make,gdb,gprof), other Linux/Unix code development tools (valgrind, ddd), database (MySQL/sqlite), scientific computing (Matlab, Mathematica, Tecplot, ANSYS), design (fontforge, GIMP, Inkscape, PhotoShop, Illustrator), layout (LaTeX, metapost, HTML web design, OpenOffice), cross-platform native program development (Lazarus/Kylix/C++Builder/Delphi)
Other
Parallel Computing (OpenMP & MPI) GPU computing with CUDA, BrookGPU and Brook+ System administrator for non-for-profit organizations Web and 2D graphics design Font design Active contributor for Fedora/Ubuntu/Debian projects

Open-Source Projects

Project About Role Notes

[WenQuanYi Project][(zh)] An online collaborative font development project founder and maintainer we developed the default Chinese desktop fonts for Ubuntu 8.04+ and Fedora 8+ among others, [a finalist project (Most Collaborative Project) of SourceForge Community Choice Awards 2007.], see [today's update]

[iso2mesh] a 3D volumetric & surface mesh generator for Matlab/Octave founder and maintainer [poster presented at IEEE ISBI'09]

[wiki2] a compact object-oriented wiki engine founder and maintainer this wiki engine support sqlite/flat file dual-backend, hierarchical page structure, object-oriented wiki data and international language

[Monte Carlo eXtreme (MCX)] photon migration simulation running on a GPU founder and maintainer code will be available as open-source software once the paper review is complete

[CreekGPU] an open-source GPU computing platform maintainer this project was derived from [BrookGPU] by Ian Buck et al.

Fedora Project GNU/Linux distribution by Redhat contributor and package maintainer

Project	About	Role	Notes
[WenQuanYi Project][(zh)]	An online collaborative font development project	founder and maintainer	we developed the default Chinese desktop fonts for Ubuntu 8.04+ and Fedora 8+ among others, [a finalist project (Most Collaborative Project) of SourceForge Community Choice Awards 2007.], see [today's update]
[iso2mesh]	a 3D volumetric & surface mesh generator for Matlab/Octave	founder and maintainer	[poster presented at IEEE ISBI'09]
[wiki2]	a compact object-oriented wiki engine	founder and maintainer	this wiki engine support sqlite/flat file dual-backend, hierarchical page structure, object-oriented wiki data and international language
[Monte Carlo eXtreme (MCX)]	photon migration simulation running on a GPU	founder and maintainer	code will be available as open-source software once the paper review is complete
[CreekGPU]	an open-source GPU computing platform	maintainer	this project was derived from [BrookGPU] by Ian Buck et al.
Fedora Project	GNU/Linux distribution by Redhat	contributor and package maintainer

On-line JavaScript programs

Program	About	Demo
[Fontopia(cn)]	an online font development environment, coauthored with mozbug	[Demo 1],[Demo 2]
[Canvas]	An HTML5 canvas-based CJK character drawing program, coauthored with mozbug	[Flash Demo]
[Pixel]	A bitmap font on-line development utility
[Wiki-based Bugzilla]	this is a plugin for wiki2 engine to allow trackers for projects	[Bug Tracker Demo]